The current status of dental education and the dental profession in Chile

Indexación: Scopus.Objective: To describe the current situation of the dental profession in Chile, including training and workforce issues. Material and Methods: Data were collected from different national institutions, which included information regarding number of current registered dentists, university of graduation, geographical distribution, professional position, additional specialty certifications obtained, the number and characteristics of dental surgeons who work in the public and private sectors, the traditional character of the university, the accreditation status of the undergraduate dental programs and the general population number. Results: Currently there are 32 schools of Dentistry in Chile, of which 21 have their quality certified. There are 19,100 Chilean dentists and 1,727 foreign dentists registered. The number of graduates from private universities has increased significantly. Currently, 2,164 dentists work for MINSAL. Less than a third hold a specialty certification. Forty-five percent of the dental specialists obtained their certification from universities. The current professional ratio is 104 dentists per 100,000 habitants. Conclusion: The number of dentists in Chile has increased progressively during the last years, mainly associated with the opening of new dental schools. Only 28% of the Chilean dental schools have certified their quality for the total duration of the undergraduate program. Regarding the workforce, there is a public/private and geographical inequities in dentists’ distribution.http://revista.uepb.edu.br/index.php/pboci/article/view/3875/pd

Critical behavior of ferromagnetic pure and random diluted nanoparticles with competing interactions: variational and Monte Carlo approaches

The magnetic properties and critical behavior of both ferromagnetic pure and metallic nanoparticles having concurrently atomic disorder, dilution and competing interactions, are studied in the framework of an Ising model. We have used both the free energy variational principle based on the Bogoliubov inequality and Monte Carlo simulation. As a case of study for random diluted nanoparticles we have considered the Fe$_{0.5}$Mn$_{0.1}$Al$_{0.4}$ alloy characterized for exhibiting, under bulk conditions, low temperature reentrant spin glass (RSG) behavior and for which experimental and simulation results are available. Our results allow concluding that the variational model is successful in reproducing features of the particle size dependence of the Curie temperature for both pure and random diluted particles. In this last case, low temperature magnetization reduction was consistent with the same type of RSG behavior observed in bulk in accordance with the Almeida-Thouless line at low fields and a linear dependence of the freezing temperature with the reciprocal of the particle diameter was also obtained. Computation of the correlation length critical exponent yielded the values $\nu=0.926\pm 0.004$ via Bogoliubov and$\nu =0.71\pm 0.04$ via Monte Carlo. This fact indicates that even though thermodynamical models can be indeed used in the study of nanostructures and they can reproduce experimental features, special attention must be paid regarding critical behavior. From both approaches, differences in the $\nu$ exponent with respect to the pure Ising model agree with Harris and Fisher arguments.Comment: 11 pages, 11 figures. Submitted to Phys. Rev.

Zastosowanie programu gwarancji dla zdrowia jamy ustnej w opiece nad kobietą w ciąży w rodzinnym centrum zdrowia w Concepción, Chile, w latach 2014–2015

Indexación: Scopus.Background. Oral health plays a crucial role in general health, quality of life and well-being of pregnant women and their newborns. In Chile, pregnant women have dental care guaranteed by law. However, due to the lack of previous epidemiological studies on the benefits of this guarantee, it is necessary to describe this situation and evaluate the need to change the methods of providing dental services. Objectives. The objective of this study was to describe the pattern of providing dental benefits resulting from the Explicit Health Guarantee – Integral Oral Health in Pregnant Women (GES-SOIE) program to pregnant women attending the Juan Soto Fernández Family Health Center, Concepción, Chile, in 2014–2015. Material and methods. A cross-sectional study of the electronic dental records of patients admitted to GES-SOIE was conducted. The variables studied were sociodemographic data, dental chair hours, non-attendance, treatment completion, and the type of referral to secondary healthcare (SHC). Results. Of 233 pregnant women, 65.2% were registered for non-attendance, 21.2% required referral to SHC and 76.4% completed their treatment. When performing logistic regression, it was found that for each non-attendance the chance of not completing the treatment increased 1.4 times. Conclusions. The level of non-attendance and opting out of the treatment in pregnant women is high, which hinders the proper functioning and effectiveness of GES-SOIE. © 2018 by Wroclaw Medical University and Polish Dental Society.http://www.dmp.umed.wroc.pl/en/article/2018/55/2/179

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles

Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/ A/dDt c(lhatbt.pw:/e/dbstc.cloabm.w/seobfst.wcoamre/-stoofotlws aarned-tools and http://teqip.jdvu.ac.in/QSAR_Tools/). SDG. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. This is the first combined comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) study in a series of selective aryloxypropanolamines displaying anti-diabetes and anti-obesity pharmacological profiles. The best CoMFA and CoMSIA models presented values of r2 ncv = 0.993 and 0.984 and values of r2 test = 0.865 and 0.918, respectively. The results obtained were subjected to extensive external validation (q2, r2, r2 m, etc.) and a final series of compounds was designed and their biological activity was predicted (best pEC50 = 8.561). © 2018 by the authors.https://www.mdpi.com/1420-3049/23/5/119